Showing posts with label Science. Show all posts
Showing posts with label Science. Show all posts

Thursday, July 3, 2025

Tracing the Roots of Anesthesia: From Sushruta to Modern India

One of the most important turning points in medical history was the creation of anesthesia. It made surgery a precise and compassionate science instead of a cruel and agonising experience. Key events like the first public demonstration of ether anesthesia in the United States in 1846 are part of the well-documented history of anesthesia worldwide. But the story of India's role in anesthesia, both historically and currently, is complex and frequently overlooked. With a focus on Indian heritage, development, and contributions, this essay examines the history of anesthesia.


120.1) Ancient Indian Origins: Sushruta and Early Concepts of Anesthesia

The Sushruta Samhita, an old Sanskrit book on medicine and surgery that dates to about 600 BCE, is where India first experimented with anaesthesia. Often referred to as the "Father of Surgery," Sushruta explained intricate surgical techniques, including how to control pain. The use of wine (madya) as a sedative and pain reliever is well documented, even if he did not employ anaesthesia in the contemporary pharmacological sense. In order to reduce discomfort during surgery, patients were frequently forced to consume herbal mixtures diluted with wine or cannabis.

Even though they were primitive, these early sedative techniques show how the Indians understood the importance of pain management during surgery. Sushruta also placed a strong emphasis on post-operative care, hygiene, and patient comfort—elements that would later form the basis of contemporary anesthesiology.

120.2) Colonial Influence and the Introduction of Modern Anesthesia in India

Modern anaesthesia techniques were brought forth by the entrance of Western medicine during the British colonial era. Only a year after its initial use in Boston, ether anaesthesia was first used in India in Calcutta (now Kolkata) in 1847. A British doctor in Calcutta named Dr. O'Shaughnessy was instrumental in bringing ether and chloroform anaesthesia knowledge to India.

Chloroform use in Indian hospitals increased by the late 19th and early 20th centuries, especially in important cities like Calcutta, Madras (Chennai), and Bombay (Mumbai). Anesthesiology was not yet a separate medical specialty, though. Usually, nurses, untrained helpers, or surgeons themselves would give anesthesia.

120.3) Post-Independence Growth and Institutionalization

Following India's independence in 1947, the country's anesthesia scene started to undergo substantial transformation. As surgical procedures increased and medical technology advanced, the demand for specialised anesthesiologists grew more apparent.

An important turning point in the professionalisation of anesthesia in India was the founding of the Indian Society of Anesthetists in 1949 (now known as the Indian Society of Anesthesiologists, or ISA).

Over time, medical schools all over India started providing specialised anesthesiology training. The MD and DNB (Diplomate of National Board) programs were introduced after the first postgraduate diploma (DA) in anesthesia.

The Journal of Anesthesiology Clinical Pharmacology and other scholarly forums were established to aid in research and knowledge exchange among Indian physicians.

120.4) Technological and Educational Advances

In India, anaesthetic methods, monitoring equipment, and safety procedures have advanced rapidly during the past few decades. Indian anaesthesiologists have moved from using basic face masks and ether drips to using cutting-edge tools like ventilators, multi-parameter monitors, and sophisticated regional blocks guided by ultrasound.

Beyond the conventional boundaries of the operating room, India has also achieved notable advancements in the fields of pain management, critical care, and palliative anesthesia. A number of Indian universities have emerged as premier hubs for anesthesiology education and research, notably CMC Vellore, PGIMER (Postgraduate Institute of Medical Education and Research), and AIIMS (All India Institute of Medical Sciences).

120.5) Challenges and the Road Ahead

India still has particular difficulties in providing safe and affordable anesthesia, despite tremendous advancements:

120.5.1) There is still a scarcity of qualified anesthesiologists in rural and impoverished areas.

120.5.2) The public's knowledge of anesthesiologists' roles in critical care and surgery is lacking.

120.5.3) The safe use of contemporary anesthetic procedures is frequently hampered by infrastructure constraints in smaller facilities.

The Indian government and medical associations have implemented telemedicine-based support systems in remote areas and started training programs for non-physician anesthetists in order to solve these issues. International partnerships, research collaborations, and simulation-based training are likewise becoming more and more popular.

120.6) Conclusion

The history of anesthesia in India is an intriguing one, combining traditional knowledge with contemporary advancements. India has made a substantial contribution to the international anesthetic community with everything from the herbal sedatives of Sushruta to innovative methods in robotic surgery and pain management. Anesthesiology is in a position to become even more important as the country's healthcare system continues to be strengthened, guaranteeing millions of people safe, fair, and painless surgical care.

In addition to being a chronicle of medical advancement, India's history of anesthesia reflects the nation's changing views on science, human dignity, and healing.


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Adarsh Tiwari

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Thursday, May 1, 2025

Mood Swings: Story of Hormones


The human body's specialised glands create hormones, which are biochemical messengers. After being released straight into the bloodstream, these molecules reach their intended organs and tissues, where they control a variety of physiological functions. Hormones are essential for preserving homeostasis, or the internal balance of the organism, which affects everything from development and metabolism to mood and reproduction.


111.1) Hormone-Producing Glands

Numerous glands that create distinct kinds of hormones make up the human endocrine system:

1) The pituitary gland, also known as the "master gland," secretes a number of hormones that control other endocrine glands. These consist of:

    1.1) Growth hormone (GH): Promotes cell division and growth.

    1.2) Adrenocorticotropic hormone (ACTH): Causes the adrenal glands to release cortisol.

    1.3) Thyroid-stimulating hormone (TSH): Encourages the production of thyroid hormone.

2) The thyroid gland, which is situated in the neck, generates hormones that control metabolism.

    2.1) Triiodothyronine (T3) and thyroxine (T4): Affect development and raise metabolic rate.

    2.2) Calcitonin: Assists in controlling blood calcium levels.

3) Parathyroid Glands: These tiny glands, which are located behind the thyroid, generate:

    3.1) By promoting bone resorption, parathyroid hormone (PTH) raises calcium levels in the blood.

4) The adrenal glands, which are situated above the kidneys, are responsible for the production of many hormones.

    4.1) Cortisol: Aids in metabolic regulation and the body's reaction to stress.

    4.2) Aldosterone: Regulates blood pressure by bringing potassium and salt levels into balance.

    4.3) The body is primed for "fight or flight" reactions by the chemicals adrenaline (epinephrine) and             noradrenaline (norepinephrine).

5) The pancreas is a gland that has both endocrine and exocrine functions.

    5.1) Insulin: Promotes the absorption of glucose into cells, lowering blood glucose levels.

    5.2) Glucagon: Encourages the liver to break down glycogen, which raises blood glucose levels.

6) The brain's pineal gland secretes the following:

    6.1) Melatonin: Controls the circadian rhythm, or sleep-wake cycle.

7) Sex glands, or gonads:

    7.1) Female ovaries: Generate progesterone and oestrogen, which control secondary sexual traits, the             menstrual cycle, and reproductive function.

    7.2) Male testes: Generate testosterone, which is in charge of sperm production and secondary sexual             characteristics in males.

8) Thymus: During the early stages of life, it generates:

    8.1) Thymosin: Essential for the immunological response, it plays a role in the formation of T-cells.


111.2) Hormones and Human Emotions:

A number of hormones have significant impacts on human emotions and mental health in addition to controlling bodily functions.  These consist of:

1) Dopamine: Often referred to as the "reward hormone," dopamine is linked to motivation, pleasure, and the reward system in the brain. Feelings of contentment and happiness are influenced by an increase in dopamine.

2) Often referred to as the "feel-good hormone," serotonin plays a role in mood, hunger, and sleep regulation.  Anxiety and sadness are associated with low serotonin levels.

3) Frequently called the "love hormone" or "bonding hormone," oxytocin fosters emotions of empathy, trust, and social bonding. It is released during nursing, childbirth, and hugs.

4) Natural medications that also provide a feeling of euphoria are called endorphins.  Exercise, laughter, and great delight all cause the release of endorphins.

5) Cortisol: Despite being predominantly a stress hormone, prolonged exposure to elevated cortisol levels can cause despair, anxiety, and irritability.

6) Adrenaline (Epinephrine): This hormone can cause sensations of thrill or anxiety and is released in response to excitement or fear.  Although it primes the body for rapid response, persistent stress can also make people anxious.

7) Changes in the hormones oestrogen and progesterone, particularly during the menstrual cycle, pregnancy, or menopause, can affect mood, irritability, and emotional sensitivity.

8) Testosterone: Known for its influence on masculine physical characteristics, testosterone also has an impact on aggression, mood, and confidence.  Emotional balance can be affected by both high and low levels.


111.3) Functions and Importance

Coordinating intricate body processes requires hormones.  For instance:

111.3.1) Insulin and thyroid hormones control metabolism.

111.3.2) Growth hormone and sex hormones regulate growth and development.

111.3.3) Sex hormones, such as oestrogen, progesterone, and testosterone, regulate reproduction.

111.3.4) Adrenaline and cortisol control stress reactions.

111.3.5) Hormones such as serotonin, dopamine, and oxytocin have a significant impact on emotions and mental health.


111.4) Hormonal Imbalance

Excessive or insufficient hormone production can cause a number of health problems. For instance:

111.4.1) Insulin resistance or insufficiency causes diabetes mellitus.

111.4.2) Thyroid hormone imbalances are the cause of both hyperthyroidism and hypothyroidism.

111.4.3) There is an excess of cortisol in Cushing's syndrome.

111.4.4) Reproductive hormone abnormalities are associated with polycystic ovarian syndrome (PCOS).

111.4.5) Serotonin, dopamine, and other mood-regulating hormone abnormalities are frequently linked to emotional illnesses like sadness, anxiety, and mood swings.


111.5) Conclusion

The human body cannot function properly without hormones. They are produced by the endocrine system and control essential functions like development, metabolism, reproduction, emotions, and stress reactions. Hormones have an impact on emotional stability and mental health in addition to physical health. Knowing how these potent compounds work aids in enhancing quality of life, identifying illnesses, and encouraging health.


Team Yuva Aaveg-

Adarsh Tiwari

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